Hepatocareinogenicity of Griseofulvin following Parenteral Administration to Infant Mice1
نویسنده
چکیده
Random-bred infant Swiss mice were injected subcutaneously with suspensions of griseofulvin in tricaprylin according to various dosage schedules. Doses of griseofulvin in excess of 0.25 mg on Day 1 of life produced acute toxicity. Following a total dosage of 3.0 mg in infant mice. 0.5, 0.5, 1.0, and 1.0 mg at ages of 1, 7, 14, and 21 days, respectively, a high incidence of hepatomata, in 44% of 16 male mice alive at 49 weeks, devel oped in comparison with solvent controls, 8% of 48 males.
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